DERMACELL
Controlled release system based on complex micro-colloidal 3D architectures based on bacterial cellulose and hydrogels for wound healing
The present project aims to develop a controlled-release system of complex micro-colloidal architecture based on bacterial cellulose and hydrogels for the management of chronic wounds. Chronic dermal wounds therapy is a topical topic with a significant global impact. These types of chronic wounds require special clinical care because any treatment that is inappropriate to the needs can lead to a delay in healing or even the development of infections. In the literature, there are data on the use of non-lyophilized bacterial cellulose to obtain dermal dressings, especially for the treatment of wounds suffered as a result of burns. These dressings do not provide complete care, which involves the protection of wounds and the delivery of active substances necessary for tissue regeneration and stopping infections. The novelty of the project is based on the fact that the new innovative concept aims to overcome these limitations of classical treatments by developing new types of dressings based on two porous 3D architectural models based on bacterial cellulose to provide a complex treatment. The complexity of the treatment is due to the synergistic effect of the bandage components. Thus, the support of the porous 3D porous structures based on bacterial cellulose is able to provide protection against the outside environment, maintain a moist environment, absorb the secretions of the exudate, allow the oxygen to pass and not to create a stressful condition for the wound.